Rejuran vs Juvelook: they are not competing, they answer different complaints

Reviewed by Dr. Kang Eun-joo, Director · Updated Sep 30, 2026 · 8 min read

In short Rejuran vs juvelook is asked as though one has to win, but both are injectables, both are planned as a short course, and this clinic offers both. What separates them is what creates the change: one improves the conditions inside your skin, the other prompts your skin to build collagen.

A private treatment room at Symphony Dermatology in Sinsa, Seoul

Rejuran places polynucleotide, a chain of purified DNA fragments obtained from salmon, into the skin to improve the conditions inside it. Juvelook combines PDLLA, a biodegradable polymer, with hyaluronic acid: the HA settles the skin immediately while the PDLLA does the slower work of prompting collagen formation.

So the honest answer to which is better is that it depends on what is actually bothering you, and that is what the consultation is for. What follows is the difference laid out plainly enough that you can tell which conversation you are having before you arrive.

What creates the change in each one

Both are offered at this clinic; the choice is made at consultation
	Rejuran (PN)	Juvelook (PDLLA + HA)
Material	Polynucleotide, purified DNA fragments from salmon	PDLLA, a biodegradable polymer, with hyaluronic acid
What creates the change	Improved conditions inside the skin itself	Collagen your own skin forms around the degrading PDLLA
Where it is placed	In the skin; Rejuran i for thin areas such as around the eyes	Between the dermis and the fat tissue
When it shows	Cumulative across a course	Restoration appears from around six weeks and develops
Usual course	3 to 4 sessions at 3 to 4 week intervals	Three sessions at four-week intervals for the standard formulation
Usual intent	Texture, moisture balance, resilience	Collagen, wrinkles, firmness

Both are offered at this clinic; the choice is made at consultation

Neither of them is a filler in the sense most people mean. A filler occupies space and changes shape on the day you have it. These two change the material the skin is made of, which is slower and reads differently in a mirror.

What Rejuran actually does, in plain terms

rejuran healer benefits turns up a lot of adjectives. The three directions we describe at consultation are narrower than that, and all of them are about the condition of the skin rather than its outline.

Oil and water balance. Sebum output settles and the surface texture becomes smoother as the skin holds moisture more evenly.
Firmness. The elastic fiber network that thins with age is supported, so skin feels more resilient rather than fuller.
The skin's own recovery. Regenerative activity is stimulated, which matters most for skin weakened by irritation or frequent procedures.

That third one is why so many of the people we treat with it have had a lot of laser work already. Skin thinned by repeated lasers is one of the situations it is well matched to. The full picture is in what Rejuran is and how a course is planned.

Rejuran, Rejuran i and Rejuran HB

Before choosing between the two treatments, it is worth knowing that Rejuran itself comes in three formulations. rejuran i and rejuran hb are the two most asked about, and they are not marketing variants.

Chosen according to what your skin needs and how sensitive you are to injection
	Rejuran / Rejuran i	Rejuran HB
Composition	Polynucleotide (PN) only	PN with hyaluronic acid and lidocaine
What it adds	The full dose is given over to PN	Hydration from HA, and less discomfort during injection
Usual delivery	Needle-free Mirajet, or hand injection	Hand injection or automated injector
Where it suits	Rejuran i is used for thin skin such as around and under the eyes	Broader facial areas where hydration is also wanted

Chosen according to what your skin needs and how sensitive you are to injection

What to expect afterwards

rejuran side effects is a fair thing to search, and the fair answer is that any injectable has something to expect. What we can tell you in advance is the part that is predictable: with needle delivery, small raised bumps are normal and usually absorb within about a day. With needle-free Mirajet there are none to wait out, which is why it is often chosen when a flight home is booked for the same evening.

Beyond that, what applies to you depends on your skin, your medication history and what else you are having done. Those are gone through at consultation rather than listed on a page, and you can reach us afterwards if something does not look the way you expected. Both treatments allow a same-day return to normal activity.

The corridor between private treatment rooms at Symphony Dermatology in Seoul — Each treatment takes place in a private single room.

How to choose, or whether to choose at all

If the complaint is texture, dryness or skin that feels thin, the conversation starts with Rejuran.
If the complaint is firmness and lines where the skin has lost its underlying support, it starts with Juvelook, and what Juvelook does and how it is planned goes into the particle sizes.
If the complaint is contour or volume, neither of these is the answer, and we will say so rather than sell you a course.
If it is more than one of the above, they are frequently planned together. Rejuran is one of the materials we combine inside a Symphony Custom Booster session.

The doctor who plans the treatment is the one who performs it, and skin is measured with our analysis system before the plan is drawn rather than after. Costs for the Rejuran side are broken down in how the price is built. The clinic is in Sinsa, central Seoul, and directions are on the visiting page.

Questions patients ask us

Rejuran vs Juvelook, which should I choose?

It depends on the complaint. Rejuran works on skin quality, meaning texture, moisture balance and resilience. Juvelook works through collagen your own skin forms around the degrading PDLLA, which suits firmness and lines. Both are offered here and the choice is made at consultation.

Can I have both?

They are frequently planned together, and Rejuran is one of the materials we combine inside a Symphony Custom Booster session. What is combined, and in what order, is decided at consultation.

What is the difference between Rejuran i and Rejuran HB?

Rejuran i is polynucleotide only and is used for thin skin such as around and under the eyes. Rejuran HB adds hyaluronic acid and lidocaine, which brings hydration and less discomfort during injection, and suits broader facial areas.

What are the side effects of Rejuran?

With needle delivery, small raised bumps are normal and usually absorb within about a day; with needle-free Mirajet there are none to wait out. What else applies to you depends on your skin and medication history, and is gone through at consultation.

How soon will I see a difference?

They differ here. Rejuran changes accumulate across a course at 3 to 4 week intervals. With Juvelook, restoration appears from around six weeks as collagen forms around the degrading PDLLA. Response varies between individuals.

Is either of them a filler?

Not in the sense of adding volume or changing contour on the day. Both change the condition of the skin rather than its outline. If shape is what you want changed, that is a different conversation and we will tell you so.

Sources

Treatment details: Symphony Skin Clinic treatment information, checked Sep 30, 2026.

This page is general information from Symphony Skin Clinic, not a diagnosis. Results, risks and recovery differ by person. Treatment is decided after an in-person consultation with a licensed doctor. Clinic and treatment photos on this page were taken at Symphony Skin Clinic.